Mixing The Astra Zeneca Vaccine With Another

[LordLucifer]

The Aust. Govt. has committed to purchasing the Astra Zeneca vaccine and the roll out of inoculations will start shortly.

However, given there is scepticism over using this one due to the supposed 67% efficiency, if the Govt. was to bring in an alternative vaccine as well, what potential effect would getting inoculated with more than one have on a person ??

Would this be a dangerous thing ??

 

[The 747]

The Aust. Govt. has committed to purchasing the Astra Zeneca vaccine and the roll out of inoculations will start shortly.

However, given there is scepticism over using this one due to the supposed 67% efficiency, if the Govt. was to bring in an alternative vaccine as well, what potential effect would getting inoculated with more than one have on a person ??

Would this be a dangerous thing ??

Unknown, there are some studies starting. Lots of variables and regulatory complications but it is a question that needs answering.

 

[Atavistic]

Best info I could find:

https://www.sciencemag.org/news/202...id-19-vaccines-scientists-are-seeking-answers

One mixed vaccine trial is already underway: It is examining matching a dose of the Sputnik V vaccine made by Russia’s Gamaleya Research Institute of Epidemiology and Microbiology with a booster dose of a similar vaccine made by AstraZeneca and the University of Oxford. A second trial, examining a combination of the AstraZeneca-Oxford and Pfizer-BioNTech vaccines, which mixes two different technologies, is just getting started, and others are under discussion.

https://www.bbc.com/news/health-55924433

A UK trial has been launched to see if giving people different Covid vaccines for their first and second doses works as well as the current approach of using the same type of vaccine twice.

Vaccines Minister Nadhim Zahawi said the government's taskforce had given about £7m to fund the study, but that findings would not be available until the summer and therefore "at the moment, we're not changing anything at all".

So hopefully the AZ and Pfizer combination works well, because the AZ vaccine isn't very effective against the SA variant, from what I've read.

 

[The City Boyz]

The Aust. Govt. has committed to purchasing the Astra Zeneca vaccine and the roll out of inoculations will start shortly.

However, given there is scepticism over using this one due to the supposed 67% efficiency, if the Govt. was to bring in an alternative vaccine as well, what potential effect would getting inoculated with more than one have on a person ??

Would this be a dangerous thing ??

Efficacy has now been upgraded to 82.4% according to the Lancet

 

[Lavender Bushranger]

What does the 82% figure mean?

Does that mean tha it works perfectly in 82 out of 100 people?

Or does it mean that it is only 82% effective at preventing the COVID symptoms? (ie. 100% is you don't get sick at all, so you'll just get 18% as sick as you would without it)

And is it an average across all people that have taken it?

 

[BillHickman]

What does the 82% figure mean?

Does that mean tha it works perfectly in 82 out of 100 people?

Or does it mean that it is only 82% effective at preventing the COVID symptoms? (ie. 100% is you don't get sick at all, so you'll just get 18% as sick as you would without it)

And is it an average across all people that have taken it?

Efficacy is a measure of how effective the vaccine is compared to placebo. You have 20,000 people in a trial and you vaccinate 10,000 and give the other 10,000 a placebo...then you let them wander around London for a week...then bring them back in and test them for Corona. If 10 people in the vaccinated group test positive, and 100 people in the placebo group test positive, then the efficacy is 10/100 = 90% effective.

In the trials, I think 'positive' means you were positive in the PCR test + you had 1 symptom.

They don't actually test strength of immune response ie. does the vaccine stop you getting Covid full stop... or does it simply stop severe disease.

 

[Aristotle Pickett]

The Aust. Govt. has committed to purchasing the Astra Zeneca vaccine and the roll out of inoculations will start shortly.

However, given there is scepticism over using this one due to the supposed 67% efficiency, if the Govt. was to bring in an alternative vaccine as well, what potential effect would getting inoculated with more than one have on a person ??

Would this be a dangerous thing ??

It's a really stupid idea to mix different vaccines.
The Pfizer vaccine is the best by a long shot but only a few in Australia will get this one.
The Astra-Zenica vaccine is better than nothing but not great against the variants.
Any approved vaccine with lessen your symptoms and reduce your risk of death.
Australia will dump the Astra-Zenica vaccine when the very very good Novavax vaccine is available.

 

[LordLucifer]

Australia will dump the Astra-Zenica vaccine when the very very good Novavax vaccine is available.

So does that mean if you have had the Astra Zeneca jab you shouldn't have the Novavax ??

 

[Aristotle Pickett]

So does that mean if you have had the Astra Zeneca jab you shouldn't have the Novavax ??

Only England are suggesting they might mix and match vaccines I think.
It would be a good chance of being safe to do so, but there's no research on that yet as far as I know.
We made need to get a new vaccine every year to two years. This would definately be safe even if different vaccines.

 

[BillHickman]

Be interesting to see which technologies people are comfortable with...or if they even care. Pfizer and Moderna are viral mRNA in lipid, AstraZeneca is viral DNA in a vector and Novavax is an old school protein vaccine. Protein vaccines have been around for decades and have a history of being effective and safe. mRNA vaccines, apart from the recent clinical trials, have never been used on human populations....so if you are happy being a guinea pig, go for it. Either way, its crucial to pick one and get the jabs, this virus has a pool of 7 billion people it can infect and each infected person may be the source of a new, worse strain. The longer its around, the higher the risk we will end up with multiple strains that will make the UK strain look like a little sniffle.

 

[Dan]

Would this be a dangerous thing ??